Limited effective reassortment shapes influenza dynamics in a human host

Limited effective reassortment shapes influenza dynamics in a human host Ashley Sobel Leonard, Micah T. McClain, Gavin J. D. Smith, David E. Wentworth, Rebecca A. Halpin, Xudong Lin, Amy Ransier, Timothy B. Stockwell, Suman R. Das, Anthony S. Gilbert, Rob Lambkin-Williams, Geoffrey S. Ginsburg, Christopher W. Woods, Katia Koelle, Christopher J. R. Illingworth6,7∗ 1 Department of Biology, Duke University, Durham, USA 2 Duke Center for Applied Genomics and Precision Medicine, Durham, NC, USA 3 Programme in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, 169857, Singapore 4 J. Craig Venter Institute, Rockville, Maryland, USA 5 hVivo PLC, The QMB Innovation Centre, Queen Mary, University of London, 42 New Road, London, UK 6 Department of Genetics, University of Cambridge, Cambridge, UK 7 Department of Applied Maths and Theoretical Physics, Centre for Mathematical Sciences, Wilberforce Road, University of Cambridge, Cambridge, UK 8 Current address: Centers for Disease Control and Prevention, MS-G16, 1600 Clifton Road, Atlanta, GA 30333, United States ∗ E-mail: Corresponding [email protected]